Abstract
In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced physical activity. We propose the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Basic Helix-Loop-Helix Transcription Factors / genetics*
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Basic Helix-Loop-Helix Transcription Factors / metabolism
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Gene Deletion
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Genetic Linkage
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Humans
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Mice
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Mice, Knockout
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Motivation
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Motor Activity / genetics*
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Obesity / genetics
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Transcription Factors / deficiency
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Transcription Factors
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NHLH2 protein, human