Role of glutathione S-transferase (GSTM1) gene polymorphism in development of uterine fibroids

Emerson de Oliveira; Rodrigo de Aquino Castro; Mariano Tamura Vieira Gomes; Ismael Dale Cotrim Guerreiro da Silva; Edmund Chada Baracat; Geraldo Rodrigues de Lima; Marair Gracio Ferreira Sartori; Manoel João Batista Castello Girão

doi:10.1016/j.fertnstert.2008.07.1767

Role of glutathione S-transferase (GSTM1) gene polymorphism in development of uterine fibroids

Fertil Steril. 2009 Apr;91(4 Suppl):1496-8. doi: 10.1016/j.fertnstert.2008.07.1767. Epub 2008 Oct 1.

Authors

Emerson de Oliveira¹, Rodrigo de Aquino Castro, Mariano Tamura Vieira Gomes, Ismael Dale Cotrim Guerreiro da Silva, Edmund Chada Baracat, Geraldo Rodrigues de Lima, Marair Gracio Ferreira Sartori, Manoel João Batista Castello Girão

Affiliation

¹ Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil. emerson.gineco@unifesp.epm.br

PMID: 18829006
DOI: 10.1016/j.fertnstert.2008.07.1767

Abstract

Glutathione S-transferase (GSTM1) plays an important role in the excretion of catechol estrogens and is therefore a candidate marker for fibroids. However, this case-control study demonstrated no association between GSTM1 polymorphism and the risk of leiomyoma in Brazilian women.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brazil
Case-Control Studies
Female
Gene Frequency / genetics
Genetic Predisposition to Disease / genetics
Genotype
Glutathione Transferase / genetics*
Humans
Leiomyoma / ethnology
Leiomyoma / genetics*
Polymorphism, Genetic / genetics*
Risk Factors

Substances

Glutathione Transferase
glutathione S-transferase M1