Hirudin in disseminated intravascular coagulation

Haemostasis. 1991:21 Suppl 1:142-8. doi: 10.1159/000216276.

Abstract

Various reactions of disseminated intravascular coagulation (DIC) were experimentally induced by infusion of thrombokinase in rats, by administration of endotoxin in rabbits and pigs and by infusion of adrenaline and thrombin in dogs. Low plasma concentrations of recombinant hirudin (r-hirudin; 20-200 ng/ml) were sufficient for the inhibition of the different triggering mechanisms. The studies on the pharmacological profile of r-hirudin in DIC therapy confirm the efficacy of this specific tight-binding thrombin inhibitor.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Disease Models, Animal
  • Disseminated Intravascular Coagulation / chemically induced
  • Disseminated Intravascular Coagulation / prevention & control*
  • Dogs
  • Endotoxins / antagonists & inhibitors
  • Endotoxins / toxicity
  • Epinephrine / antagonists & inhibitors
  • Epinephrine / toxicity
  • Factor Xa / toxicity
  • Factor Xa Inhibitors
  • Female
  • Fibrinolytic Agents / pharmacology
  • Fibrinolytic Agents / therapeutic use
  • Hemodynamics / drug effects
  • Hirudin Therapy
  • Hirudins / analogs & derivatives*
  • Hirudins / pharmacology
  • Lipid A / antagonists & inhibitors
  • Lipid A / toxicity
  • Male
  • Platelet Count / drug effects
  • Rabbits
  • Rats
  • Rats, Inbred Strains
  • Recombinant Proteins / pharmacology
  • Recombinant Proteins / therapeutic use
  • Species Specificity
  • Swine
  • Thrombin / antagonists & inhibitors
  • Thrombin / toxicity
  • Thrombolytic Therapy
  • Thrombosis / chemically induced
  • Thrombosis / drug therapy
  • Viscera / blood supply

Substances

  • Endotoxins
  • Factor Xa Inhibitors
  • Fibrinolytic Agents
  • Hirudins
  • Lipid A
  • Recombinant Proteins
  • Thrombin
  • Factor Xa
  • desirudin
  • Epinephrine