Cerebral sinus venous thrombosis in a subject with thyrotoxicosis and MTHFR gene polymorphism

Laura Strada; Carlo Gandolfo; Massimo Del Sette

doi:10.1007/s10072-008-0992-4

Cerebral sinus venous thrombosis in a subject with thyrotoxicosis and MTHFR gene polymorphism

Neurol Sci. 2008 Oct;29(5):343-5. doi: 10.1007/s10072-008-0992-4. Epub 2008 Oct 21.

Authors

Laura Strada¹, Carlo Gandolfo, Massimo Del Sette

Affiliation

¹ Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, Genoa, Italy. mdelsette@neurologia.unige.it

PMID: 18941937
DOI: 10.1007/s10072-008-0992-4

Abstract

We report a case of cerebral venous thrombosis (CVT) due to tyrotoxicosis in a patient with methylenetetrahydro-folate-reductase (MTHFR) gene polymorphism C677T, (genotype 677TT), in which discontinuation of intravenous heparin was followed by clinical and radiological worsening despite warfarin treatment. We discuss the relationship between CVT, MTHFR hyperthiroidism and anticoagulant therapy.

Publication types

Case Reports

MeSH terms

Adult
Anticoagulants / therapeutic use
Heparin / therapeutic use
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Polymorphism, Genetic*
Sinus Thrombosis, Intracranial / drug therapy
Sinus Thrombosis, Intracranial / etiology*
Sinus Thrombosis, Intracranial / genetics*
Thyrotoxicosis / complications*
Thyrotoxicosis / genetics
Warfarin / therapeutic use

Substances

Anticoagulants
Warfarin
Heparin
Methylenetetrahydrofolate Reductase (NADPH2)