Abstract
Interleukin-6 (IL-6) is an important pro-inflammatory mediator implicated in immune-mediated complications of allogeneic haematopoietic stem cell transplantation (aHSCT). In accord with previous reports, this preliminary study on 56 donor-recipient pairs revealed IL-6-174 single nucleotide polymorphisms as a risk factor for the development of acute graft-versus-host disease and decreased survival after aHSCT.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Alleles
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Czech Republic
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Female
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Gene Frequency
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Genotype
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Graft vs Host Disease / genetics*
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Graft vs Host Disease / immunology
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Graft vs Host Disease / mortality
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Hematopoietic Stem Cell Transplantation / adverse effects*
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Hematopoietic Stem Cell Transplantation / mortality
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Humans
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Interleukin-6 / genetics*
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Interleukin-6 / immunology
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Male
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Middle Aged
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Polymorphism, Genetic / genetics*
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Polymorphism, Genetic / immunology
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Polymorphism, Single Nucleotide / genetics
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Transplantation, Homologous / immunology*
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Young Adult