Additive effect between quinine oxidoreductase gene (NQO1: Pro187Ser) and manganese superoxide dismutase gene (MnSOD: Ala-9Val) polymorphisms on tardive dyskinesia in patients with schizophrenia

Chi-Un Pae

doi:10.1016/j.psychres.2006.10.005

Additive effect between quinine oxidoreductase gene (NQO1: Pro187Ser) and manganese superoxide dismutase gene (MnSOD: Ala-9Val) polymorphisms on tardive dyskinesia in patients with schizophrenia

Psychiatry Res. 2008 Dec 15;161(3):336-8. doi: 10.1016/j.psychres.2006.10.005. Epub 2008 Oct 31.

Author

Chi-Un Pae¹

Affiliation

¹ Department of Psychiatry, Kangnam St Mary's Hospital, The Catholic University of Korea, College of Medicine, Seocho-Gu, Seoul, Republic of Korea. pae@catholic.ac.kr

PMID: 18977034
DOI: 10.1016/j.psychres.2006.10.005

Abstract

This study investigated whether there was an interaction between the NQO1 Pro187Ser and MnSOD Ala-9Val gene polymorphisms in the development of tardive dyskinesia (TD). The combined genotypes of T/T in NQO1 Pro187Ser and Val/Val in MnSOD Ala-9Val polymorphisms were found to be independently associated with a significantly higher risk of TD. However, further adequately powered studies will be needed to confirm these preliminary findings.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
Antipsychotic Agents / adverse effects*
Cross-Sectional Studies
Dyskinesia, Drug-Induced / diagnosis
Dyskinesia, Drug-Induced / genetics*
Genetic Predisposition to Disease
Genotype
Humans
Korea
Monte Carlo Method
NAD(P)H Dehydrogenase (Quinone) / genetics*
Polymorphism, Genetic / genetics*
Risk
Schizophrenia / diagnosis
Schizophrenia / drug therapy*
Schizophrenia / genetics*
Superoxide Dismutase / genetics*

Substances

Antipsychotic Agents
Superoxide Dismutase
NAD(P)H Dehydrogenase (Quinone)
NQO1 protein, human