Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients

Leukemia. 2009 May;23(5):971-4. doi: 10.1038/leu.2008.317. Epub 2008 Nov 6.
No abstract available

Publication types

  • Letter

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child
  • Drug-Related Side Effects and Adverse Reactions
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Heterozygote
  • Humans
  • Male
  • Mercaptopurine / pharmacology*
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
  • Methyltransferases / genetics*
  • Mutation / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
  • Retrospective Studies

Substances

  • Mercaptopurine
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Methyltransferases
  • thiopurine methyltransferase