Effect of methylenetetrahydrofolate reductase and thymidylate synthase enhancer region polymorphisms on the risk of idiopathic recurrent spontaneous abortion in a Korean population

Jeehyeon Bae; Dong Hee Choi; Myung Seo Kang; Sun Hee Cha; Doyeun Oh; Nam Keun Kim

doi:10.1016/j.fertnstert.2008.09.060

Effect of methylenetetrahydrofolate reductase and thymidylate synthase enhancer region polymorphisms on the risk of idiopathic recurrent spontaneous abortion in a Korean population

Fertil Steril. 2009 Apr;91(4 Suppl):1560-2. doi: 10.1016/j.fertnstert.2008.09.060. Epub 2008 Nov 6.

Authors

Jeehyeon Bae¹, Dong Hee Choi, Myung Seo Kang, Sun Hee Cha, Doyeun Oh, Nam Keun Kim

Affiliation

¹ Institute for Clinical Research, Bundang CHA General Hospital, College of Medicine, Pochon CHA University, Seongnam, South Korea.

PMID: 18990369
DOI: 10.1016/j.fertnstert.2008.09.060

Abstract

Previous studies reported an association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms and recurrent spontaneous abortion, whereas no studies are available for the association with thymidylate synthase enhancer region (TSER) genotypes. Mutations of MTHFR and TSER are not likely significant risk factors of idiopathic recurrent spontaneous abortion in Korean women.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abortion, Spontaneous / ethnology*
Abortion, Spontaneous / genetics*
Adult
Case-Control Studies
Enhancer Elements, Genetic / genetics*
Female
Genetic Predisposition to Disease / genetics
Genotype
Humans
Korea
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Polymorphism, Genetic / genetics*
Recurrence
Risk Factors
Thymidylate Synthase / genetics*

Substances

Methylenetetrahydrofolate Reductase (NADPH2)
Thymidylate Synthase