Abstract
We have examined three cases of human lymphoma bearing a t(2;18)(p11;q21) chromosome translocation. The bcl-2 gene appeared to be rearranged in all three cases and breakpoints were clustered in the 5' flanking region of the gene. In all three cases, bcl-2 was juxtaposed to J segments of the Ig kappa gene. This juxtaposition of the bcl-2 and Ig kappa genes is very similar to the variant chromosome translocations of Burkitt lymphoma that juxtapose the c-myc locus to IgL genes.
Publication types
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Case Reports
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Blotting, Southern
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Chromosomes, Human, Pair 18*
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Chromosomes, Human, Pair 2*
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DNA Probes
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Female
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Humans
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Immunoglobulin kappa-Chains / genetics*
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Lymphoma, Follicular / genetics*
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Male
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Middle Aged
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins c-bcl-2
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Translocation, Genetic*
Substances
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DNA Probes
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Immunoglobulin kappa-Chains
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2