FHM3 in familial hemiplegic migraine is more resistant to mutation than FHM1 and FHM2

Viroj Wiwanitkit

doi:10.1016/j.jns.2008.10.012

FHM3 in familial hemiplegic migraine is more resistant to mutation than FHM1 and FHM2

J Neurol Sci. 2009 Feb 15;277(1-2):76-9. doi: 10.1016/j.jns.2008.10.012. Epub 2008 Nov 13.

Author

Viroj Wiwanitkit¹

Affiliation

¹ Wiwanitkit House, Bangkhae, Bangkok, 10160, Thailand. wviroj@yahoo.com

PMID: 19007941
DOI: 10.1016/j.jns.2008.10.012

Abstract

Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura and transient hemiplegia. CACNA1A (FHM1) gene, the ATP1A2 (FHM2) and the SCN1A (FHM3) are reported for their correlation to FHM. Here, a bioinformatics analysis was done to study the risk positions for mutation within the amino acid sequence of the three mentioned molecules. In this work, the author can identify many mutant prone positions within the studied FHM. Of interest, the author detected that FHM3 is a high resistant molecule when compared to FHM1 and FHM2.

Publication types

Comparative Study

MeSH terms

Amino Acid Sequence
Calcium Channels / genetics*
Computational Biology
Genetic Linkage
Genetic Predisposition to Disease / epidemiology
Humans
Migraine with Aura / classification
Migraine with Aura / epidemiology*
Migraine with Aura / genetics*
Molecular Sequence Data
NAV1.1 Voltage-Gated Sodium Channel
Nerve Tissue Proteins / genetics*
Risk Factors
Sodium Channels / genetics*
Sodium-Potassium-Exchanging ATPase / genetics*

Substances

CACNA1A protein, human
Calcium Channels
NAV1.1 Voltage-Gated Sodium Channel
Nerve Tissue Proteins
SCN1A protein, human
Sodium Channels
ATP1A2 protein, human
Sodium-Potassium-Exchanging ATPase