Severe hyperbilirubinemia in a glucose-6-phosphate dehydrogenase-deficient preterm neonate: could prematurity be the main responsible factor?

Simonetta Costa; Maria Pia De Carolis; Daniele De Luca; Immacolata Savarese; Costantino Romagnoli

doi:10.1159/000174571

Severe hyperbilirubinemia in a glucose-6-phosphate dehydrogenase-deficient preterm neonate: could prematurity be the main responsible factor?

Fetal Diagn Ther. 2008;24(4):440-3. doi: 10.1159/000174571. Epub 2008 Nov 20.

Authors

Simonetta Costa¹, Maria Pia De Carolis, Daniele De Luca, Immacolata Savarese, Costantino Romagnoli

Affiliation

¹ Division of Neonatology, Department of Pediatrics, University Hospital Agostino Gemelli, Catholic University of the Sacred Heart, Rome, Italy. imocosta@yahoo.it

PMID: 19023210
DOI: 10.1159/000174571

Abstract

We report on a premature infant with glucose-6-phosphate dehydrogenase deficiency and severe hyperbilirubinemia. In this patient, all known potential hemolytic agents were excluded and no findings of hemolysis were observed. The crucial role of prematurity in the pathogenesis of this type of jaundice is discussed.

Publication types

Case Reports

MeSH terms

Adult
Anemia, Hemolytic, Congenital / etiology
Anemia, Hemolytic, Congenital / genetics
Anemia, Hemolytic, Congenital / metabolism
Bilirubin / blood
Female
Glucosephosphate Dehydrogenase Deficiency / complications*
Glucosephosphate Dehydrogenase Deficiency / genetics*
Glucosephosphate Dehydrogenase Deficiency / metabolism
Hematocrit
Humans
Hyperbilirubinemia, Neonatal / etiology*
Hyperbilirubinemia, Neonatal / genetics*
Hyperbilirubinemia, Neonatal / metabolism
Infant, Newborn
Infant, Premature*
Male
Pregnancy
Severity of Illness Index
Triplets

Substances

Bilirubin