When the gut talks to bone

Fanxin Long

doi:10.1016/j.cell.2008.11.007

When the gut talks to bone

Cell. 2008 Nov 28;135(5):795-6. doi: 10.1016/j.cell.2008.11.007.

Author

Fanxin Long¹

Affiliation

¹ Department of Medicine and Department of Developmental Biology, Washington University Medical School, St. Louis, MO 63131, USA. flong@wustl.edu

PMID: 19041744
DOI: 10.1016/j.cell.2008.11.007

Abstract

Mutations in LRP5, a coreceptor for Wnt proteins, cause the disease osteoporosis pseudoglioma. A new study by Yadav et al. (2008) now challenges the view that LRP5 controls bone mass through Wnt signaling in bone and argues instead that LRP5 regulates bone mass indirectly through its effects on serotonin synthesis in the gut.

Publication types

Comment

MeSH terms

Animals
Bone and Bones / metabolism*
Gastrointestinal Tract / metabolism*
Humans
LDL-Receptor Related Proteins / metabolism*
Low Density Lipoprotein Receptor-Related Protein-5
Osteoporosis / genetics
Osteoporosis / metabolism
Serotonin / metabolism
Wnt Proteins / metabolism

Substances

LDL-Receptor Related Proteins
LRP5 protein, human
Low Density Lipoprotein Receptor-Related Protein-5
Wnt Proteins
Serotonin