Abstract
Growth factors in the brain are important to depression and it's treatment and we assessed the ability of peripherally administered insulin-like growth factor-I (IGF-I) to influence behavior related to depression. We found that mice that received chronic IGF-I treatment showed antidepressant-like behavior in forced-swim and novelty-induced hypophagia (NIH) tests and increased sucrose consumption after chronic mild unpredictable stress exposure. Additionally, peripheral anti-IGF-I administration blocked exercise-induced antidepressant effects in the forced-swim test (FST). These results support the functional relevance of neurotrophic mechanisms to depression and extend this idea to include neurotrophic factors in the periphery.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antidepressive Agents / pharmacology*
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Behavior, Animal / drug effects*
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Brain-Derived Neurotrophic Factor / genetics
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Brain-Derived Neurotrophic Factor / metabolism
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Depression / drug therapy*
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Depression / psychology
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Enzyme-Linked Immunosorbent Assay
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Exercise / psychology
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Humans
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Immunoglobulin G / pharmacology
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In Situ Hybridization
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Injections, Subcutaneous
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Insulin-Like Growth Factor I / administration & dosage
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Insulin-Like Growth Factor I / antagonists & inhibitors
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Insulin-Like Growth Factor I / genetics
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Insulin-Like Growth Factor I / metabolism
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Insulin-Like Growth Factor I / pharmacology
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Insulin-Like Growth Factor I / physiology*
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Male
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Mice
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Motor Activity / physiology
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Stress, Physiological / drug effects*
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Swimming / physiology
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Time Factors
Substances
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Antidepressive Agents
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Brain-Derived Neurotrophic Factor
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Immunoglobulin G
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Insulin-Like Growth Factor I