Yellow nails syndrome (YNS) is a rather rare condition. The syndrome was first described in 1964 by Samman and White. Later, Emerson added pleural effusion as a frequent feature of the disease. The classic triad of YNS includes yellow nails, lymphedema, and respiratory tract involvement, with or without sinusitis. However, these three alterations are simultaneously present in only 27 percent of cases. We describe two siblings (ages 32 and 26) with 20 yellow nails. There have been only a few published reports where a positive family history (FH) has been documented in cases of YNS.