Abstract
We evaluated the relationship between the efficacy of low-dose azathioprine (AZA) therapy and the inosine triphosphate pyrophosphatase (ITPA) 94C>A (Pro32Thr) polymorphism in patients with systemic lupus erythematosus (SLE). We performed a multiple regression analysis to assess the influence of various factors on the reduction in SLE disease activity index (SLEDAI) scores. The ITPA 94C>A polymorphism had the highest correlation with the change in SLEDAI score (r = 0.354, P = 0.006).
MeSH terms
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Adolescent
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Adult
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Aged
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Alleles
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Asian People / genetics
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Azathioprine / pharmacology
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Azathioprine / therapeutic use*
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Female
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Glutathione Transferase / genetics
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Humans
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Immunosuppressive Agents / pharmacology
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Immunosuppressive Agents / therapeutic use*
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Inosine Triphosphatase
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Japan / epidemiology
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Lupus Erythematosus, Systemic / drug therapy*
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Lupus Erythematosus, Systemic / genetics
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Male
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Methyltransferases / genetics
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Middle Aged
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Polymorphism, Genetic*
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Pyrophosphatases / genetics*
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Regression Analysis
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Retrospective Studies
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Severity of Illness Index
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Young Adult
Substances
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Immunosuppressive Agents
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Methyltransferases
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thiopurine methyltransferase
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Glutathione Transferase
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Pyrophosphatases
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Azathioprine