Abstract
Burkitt lymphoma is a unique B-cell malignancy with a high proliferation rate and characteristic genetic changes involving the c-myc oncogene. Burkitt lymphoma is common in children but also occurs in adults, where distinction from diffuse large B-cell lymphoma may pose a problem. The development of brief, very intensive chemotherapy regimens has led to a very high cure rate in children with Burkitt lymphoma. The use of these regimens in adults, often in combination with the antibody rituximab (Rituxan), has also made the cure of a majority of adults possible. Burkitt lymphoma in adults cannot be treated effectively with the common regimens used for diffuse large B-cell lymphoma such as CHOP-R (cyclophosphamide, doxorubicin HCl, vincristine [Oncovin], prednisone, rituximab). Prompt diagnosis and initiation of appropriate therapy with attention to the possibility of tumor lysis syndrome are necessary for optimal results.
MeSH terms
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Adult
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal, Murine-Derived
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Burkitt Lymphoma / diagnosis*
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Burkitt Lymphoma / drug therapy*
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Burkitt Lymphoma / genetics
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Burkitt Lymphoma / surgery
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Clinical Trials, Phase II as Topic
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Cyclophosphamide / administration & dosage
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Cytarabine / administration & dosage
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Dexamethasone / administration & dosage
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Doxorubicin / administration & dosage
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Genes, myc
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Humans
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Ifosfamide / administration & dosage
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Leucovorin / administration & dosage
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Methotrexate / administration & dosage
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Practice Guidelines as Topic
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Prednisone / administration & dosage
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Prognosis
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Rituximab
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Stem Cell Transplantation / methods
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Survival Analysis
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Teniposide / administration & dosage
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Treatment Outcome
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Vincristine / administration & dosage
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Murine-Derived
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Cytarabine
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Rituximab
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Vincristine
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Dexamethasone
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Doxorubicin
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Cyclophosphamide
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Teniposide
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Leucovorin
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Ifosfamide
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Prednisone
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Methotrexate