[Interleukin-1beta gene polymorphism as a predictor of eradication treatment efficacy in gastric and duodenal ulcer associated with Helicobacter pylori]

Eksp Klin Gastroenterol. 2008:(4):92-6.
[Article in Russian]

Abstract

The results of recent research that IL gene polymorphism powerfully affects the course and the resolve of HP infection and finally impacts its treatment. The present article into the problem of IL polymorphism impact on HP eradication therapy efficiency in ulcer disease. The presence of proinflammatory allele positively influences eradication therapy, which can be used for determining the risk groups and individualized eradication therapy.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Amoxicillin / administration & dosage
  • Amoxicillin / therapeutic use
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use
  • Anti-Ulcer Agents / administration & dosage
  • Anti-Ulcer Agents / therapeutic use
  • Clarithromycin / administration & dosage
  • Clarithromycin / therapeutic use
  • Endoscopy, Digestive System
  • Helicobacter Infections / diagnosis
  • Helicobacter Infections / drug therapy*
  • Helicobacter Infections / immunology
  • Helicobacter Infections / microbiology
  • Helicobacter pylori / drug effects*
  • Humans
  • Interleukin-1beta / genetics*
  • Middle Aged
  • Omeprazole / administration & dosage
  • Omeprazole / therapeutic use
  • Peptic Ulcer / diagnosis
  • Peptic Ulcer / drug therapy*
  • Peptic Ulcer / immunology
  • Peptic Ulcer / microbiology
  • Polymorphism, Single Nucleotide*
  • Predictive Value of Tests
  • Prospective Studies
  • Treatment Outcome
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Anti-Ulcer Agents
  • Interleukin-1beta
  • Amoxicillin
  • Clarithromycin
  • Omeprazole