Abstract
We describe the development of a Brugada ECG together with sinus- and ventricular arrest after intravenous flecainide for atrial fibrillation in a patient in whom eventually a SCN5a mutation was identified. Unrecognized SCN5A mutations could underlie class IC-induced sinus arrest and conduction defects in some patients.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Atrial Fibrillation / diagnosis*
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Atrial Fibrillation / genetics*
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Brugada Syndrome / diagnosis*
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Brugada Syndrome / genetics*
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Female
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Genetic Predisposition to Disease / genetics
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Humans
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Middle Aged
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Muscle Proteins / genetics*
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NAV1.5 Voltage-Gated Sodium Channel
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Sodium Channels / genetics*
Substances
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Muscle Proteins
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NAV1.5 Voltage-Gated Sodium Channel
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SCN5A protein, human
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Sodium Channels