Abstract
The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autism. Here, we review recent studies that provide insight into the biological roles of the ERKs in the brain that may underlie the cognitive deficits seen in these syndromes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Brain / abnormalities
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Brain / enzymology*
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Brain / physiopathology
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Child, Preschool
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Cognition Disorders / enzymology*
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Cognition Disorders / genetics
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Cognition Disorders / physiopathology
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Developmental Disabilities / enzymology*
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Developmental Disabilities / genetics
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Developmental Disabilities / physiopathology
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Extracellular Signal-Regulated MAP Kinases / genetics*
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Extracellular Signal-Regulated MAP Kinases / metabolism*
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Gene Expression Regulation, Enzymologic / genetics
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Genetic Predisposition to Disease / genetics
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Humans
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MAP Kinase Signaling System / genetics*
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Nervous System Malformations / enzymology
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Nervous System Malformations / genetics
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Nervous System Malformations / physiopathology
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Syndrome
Substances
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Extracellular Signal-Regulated MAP Kinases