Abstract
Mitochondrial uncoupling protein 1 (UCP1) is a key regulator of adaptive thermogenesis and energy expenditure. Mice lacking UCP1 are cold sensitive, but surprisingly not obese at room temperature. In this issue of Cell Metabolism, Feldmann et al. (2009) unmask an obesogenic phenotype by simply maintaining these mice at thermoneutrality.
MeSH terms
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Adipose Tissue, Brown / metabolism
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Animals
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Diabetes Mellitus / prevention & control
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Energy Metabolism*
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Humans
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Ion Channels / genetics*
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Mice
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Mice, Knockout
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Mitochondrial Proteins / genetics*
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Obesity / prevention & control
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Receptors, Adrenergic, beta / deficiency
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Temperature
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Thermogenesis*
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Uncoupling Protein 1
Substances
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Ion Channels
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Mitochondrial Proteins
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Receptors, Adrenergic, beta
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UCP1 protein, human
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Ucp1 protein, mouse
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Uncoupling Protein 1