The MLLgnant consequences of reverting to an embryonic transcriptional program

Cell Stem Cell. 2009 Feb 6;4(2):97-8. doi: 10.1016/j.stem.2009.01.008.

Abstract

In this issue of Cell Stem Cell, Somervaille et al. (2009) have demonstrated convincingly that reversion to an embryonic transcriptional program through defective MLL gene expression contributes to the generation of myeloid leukemia stem cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cellular Reprogramming
  • Gene Expression Regulation, Developmental*
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Leukemia, Myeloid, Acute / pathology
  • Leukemia, Myeloid, Acute / physiopathology
  • Myeloid-Lymphoid Leukemia Protein / genetics
  • Myeloid-Lymphoid Leukemia Protein / metabolism*
  • Neoplastic Stem Cells / physiology*
  • Transcription, Genetic*

Substances

  • KMT2A protein, human
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase