MHC molecules and microbial antigen processing in phagosomes

Curr Opin Immunol. 2009 Feb;21(1):98-104. doi: 10.1016/j.coi.2009.01.001. Epub 2009 Feb 11.

Abstract

Macrophages and dendritic cells are phagocytic antigen presenting cells that internalize bacteria and other particulate antigens into phagosomes. The phagosome must then balance microbicidal and proteolytic degradation functions with the generation of antigenic peptides for presentation by class I and class II MHC molecules to CD8 and CD4 T cells, respectively. Understanding the host and bacterial factors that affect phagosomal antigen processing may help facilitate new strategies to eliminate pathogens.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Antigens, Bacterial / immunology*
  • Antigens, Bacterial / metabolism
  • Bacterial Infections / immunology*
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / metabolism
  • Cross-Priming / genetics
  • Histocompatibility Antigens / immunology*
  • Histocompatibility Antigens / metabolism
  • Humans
  • Immunodominant Epitopes / immunology
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / immunology
  • Membrane Glycoproteins / metabolism
  • NADPH Oxidase 2
  • NADPH Oxidases / genetics
  • NADPH Oxidases / immunology
  • NADPH Oxidases / metabolism
  • Peptides / immunology
  • Phagosomes / enzymology
  • Phagosomes / immunology*
  • Phagosomes / microbiology
  • Signal Transduction
  • Toll-Like Receptors / immunology

Substances

  • Antigens, Bacterial
  • Histocompatibility Antigens
  • Immunodominant Epitopes
  • Membrane Glycoproteins
  • Peptides
  • Toll-Like Receptors
  • CYBB protein, human
  • NADPH Oxidase 2
  • NADPH Oxidases