Abstract
This study revealed the importance of 6 genetic determinants (accounting for predisposition to thrombophilia) as risk factors of thromboembolic stroke in patients with atrial fibrillation (AF). The occurrence of A-allele of FGB gene of patients with complicated form of AF was shown to be significantly higher compared with controls. Carriage of FGB-455A, grade II mitral regurgitation, and AF longer than 48 hours are assumed to be independent predictors of thromboembolic stroke.
Publication types
-
Comparative Study
-
English Abstract
MeSH terms
-
Atrial Fibrillation / complications*
-
Atrial Fibrillation / genetics
-
Brain Ischemia / epidemiology
-
Brain Ischemia / etiology
-
Brain Ischemia / genetics*
-
Coronary Thrombosis / epidemiology
-
Coronary Thrombosis / etiology
-
Coronary Thrombosis / genetics*
-
DNA / genetics*
-
Female
-
Fibrinogen / genetics*
-
Fibrinogen / metabolism
-
Genetic Predisposition to Disease
-
Humans
-
Incidence
-
Male
-
Middle Aged
-
Polymerase Chain Reaction
-
Polymorphism, Genetic*
-
Russia / epidemiology