[Association of insulinase gene polymorphisms with type 2 diabetes mellitus in patients from the Moscow population]

P A Slominskiĭ; O V Pivovarova; M I Shadrina; A V Artem'eva; F G Pfaipffer; N N Rudovich; S E Agadzhanian; V S Pronin; S A Limborskaia

[Association of insulinase gene polymorphisms with type 2 diabetes mellitus in patients from the Moscow population]

Genetika. 2009 Jan;45(1):127-31.

[Article in Russian]

Authors

P A Slominskiĭ, O V Pivovarova, M I Shadrina, A V Artem'eva, F G Pfaipffer, N N Rudovich, S E Agadzhanian, V S Pronin, S A Limborskaia

PMID: 19239107

Abstract

Association of 13 single nucleotide polymorphisms (SNPs) of insulinase (IDE) gene with type 2 diabetes mellitus (T2D) in the Moscow population has been examined. Three polymorphic markers (rs7078413, rs7899603, and rs551266) associated with the risk of T2D development have been revealed. Allele and genotype frequency distribution for these three markers differed significantly only in the sample of females between T2D patients and control individuals, while only in case of rs7078413 SNP genotype frequencies varied significantly in the total population.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Diabetes Mellitus, Type 2 / genetics*
Female
Genetic Predisposition to Disease*
Humans
Insulysin / genetics*
Male
Moscow
Polymorphism, Single Nucleotide*

Substances

Insulysin