Abstract
Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.
MeSH terms
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ADAM Proteins / genetics
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Bronchiolitis, Viral / genetics*
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Cohort Studies
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Data Interpretation, Statistical
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Genetic Predisposition to Disease*
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Humans
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Immunity, Innate / genetics*
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Infant, Newborn
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Infant, Premature
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Infant, Premature, Diseases / genetics*
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Lung / growth & development
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Polymorphism, Single Nucleotide
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Protein Serine-Threonine Kinases / genetics
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Receptor, Transforming Growth Factor-beta Type I
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Receptors, Transforming Growth Factor beta / genetics
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Respiratory Syncytial Virus Infections / genetics*
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Risk Factors
Substances
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Receptors, Transforming Growth Factor beta
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Protein Serine-Threonine Kinases
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Receptor, Transforming Growth Factor-beta Type I
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TGFBR1 protein, human
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ADAM Proteins
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ADAM33 protein, human