Association of HLA-A in autoimmune myasthenia gravis with thymoma

Claire Vandiedonck; Colette Raffoux; Bruno Eymard; Christine Tranchant; Elisabeth Dulmet; Sophie Krumeich; Philippe Gajdos; Henri-Jean Garchon

doi:10.1016/j.jneuroim.2009.02.004

Association of HLA-A in autoimmune myasthenia gravis with thymoma

J Neuroimmunol. 2009 May 29;210(1-2):120-3. doi: 10.1016/j.jneuroim.2009.02.004. Epub 2009 Mar 10.

Authors

Claire Vandiedonck¹, Colette Raffoux, Bruno Eymard, Christine Tranchant, Elisabeth Dulmet, Sophie Krumeich, Philippe Gajdos, Henri-Jean Garchon

Affiliation

¹ Inserm U and Université Paris Descartes, Institut Cochin, Department of Immunology, France.

PMID: 19278738
DOI: 10.1016/j.jneuroim.2009.02.004

Abstract

We investigated an association of the HLA-A locus in 78 French Caucasian patients with autoimmune myasthenia gravis (MG) and thymic epithelial tumours. The largest effect was a protection associated with HLA-A02 in MG patients with a B2 type thymoma (OR=0.323, 95% CI: 0.113-0.756, P=0.00041). The frequency of HLA-A25 was also increased in the whole group of patients (OR=3.62, 95% CI: 1.62-7.08, P=0.0041). Our findings emphasise the interest of the histological classification in the genetic study of thymomas.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Autoantibodies / analysis
Autoantibodies / blood
DNA Mutational Analysis
Female
France
Gene Frequency
Genetic Markers / genetics
Genetic Predisposition to Disease / genetics*
Genetic Testing
Genetics, Population
Genotype
HLA-A Antigens / genetics*
Heterozygote
Histocompatibility Testing
Humans
Male
Myasthenia Gravis / ethnology
Myasthenia Gravis / genetics*
Myasthenia Gravis / immunology*
Thymoma / genetics*
Thymoma / immunology*
Thymoma / pathology
Thymus Gland / immunology
Thymus Gland / pathology
Thymus Gland / physiopathology
White People

Substances

Autoantibodies
Genetic Markers
HLA-A Antigens
HLA-A*25 antigen