Purpose: To investigate the correlation between interleukin-1 receptor antagonist (IL-1ra) genotype and chronic periodontitis in patients with coronary heart disease.
Methods: Genomic DNA was obtained from buccal swabs in 86 patients with coronary heart disease,of which 45 patients with chronic periodontitis, the other without chronic periodontitis. Genotypes of IL-1RN intron 2 VNTR were analyzed by SSP-PCR method. Then the differences in distribution of each genotype were analyzed with SPSS 13.0 software package.
Results: A significant over-representation of IL-1 RN intron 2 VNTR allele 2 was found in patients with coronary heart disease and chronic periodontitis group (chi(2)=4.960,P=0.026).
Conclusion: IL-1RN intron 2 VNTR allele 2 may be a risk indicator for the susceptibility of chronic periodontitis in patients with coronary heart disease.