Abstract
In serum of 114 patients with dementia and of 102 controls the level of IG class immunoglobulins directed against oxidized LDL and lipids were determined. In isolated DNA apolipoprotein E gene (APOE) polymorphism was identified. In some individuals very high levels of the antibodies were observed. exceeding the 90 percentile in the investigated group. The prevalence of very high anti-ox LDL antibodies level was significantly more frequent in the carriers of epsilon2 allele and less frequent in the carriers of epsilon4 allele.
MeSH terms
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Apolipoprotein E2 / blood
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Apolipoprotein E2 / genetics
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Apolipoprotein E3 / blood
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Apolipoprotein E3 / genetics
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Apolipoprotein E4 / blood
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Apolipoprotein E4 / genetics
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Apolipoproteins E / blood
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Apolipoproteins E / genetics*
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Autoantibodies / blood*
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Cholesterol / blood
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Cholesterol, HDL / blood
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Cholesterol, LDL / blood
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Dementia / blood
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Dementia / genetics*
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Dementia / immunology*
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Female
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Genotype
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Humans
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Lipoproteins, LDL / immunology*
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Male
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Polymorphism, Genetic
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Triglycerides / blood
Substances
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Apolipoprotein E2
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Apolipoprotein E3
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Apolipoprotein E4
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Apolipoproteins E
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Autoantibodies
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Cholesterol, HDL
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Cholesterol, LDL
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Lipoproteins, LDL
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Triglycerides
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oxidized low density lipoprotein
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Cholesterol