Abstract
The prognosis of hepatocellular carcinoma (HCC) is poor and current therapies are largely ineffective. Transcatheter arterial chemoembolization is a standard treatment option for patients with unresectable HCC, especially when combined with other therapies. We report a 62-year-old male with huge HCC. The patient was first treated with adenovirus-mediated wild-type p53 gene (Ad-p53, gendicine) combined with oxaliplatin (200 mg) and transcatheter arterial chemoembolization or transcatheter arterial chemotherapy for two cycles. Review showed tumor shrinkage and a decrease in alpha-fetoprotein. Oxaliplatin was stopped because of side effects. Then the patient was treated with a tumor feeding arterial injection of Ad-p53 (1 x 10 viral particles) twice and Ad-p53 (1 x 10 viral particles) followed by 5-fluorouracil (500-750 mg) six times through port-catheter system. We observed marked tumor shrinkage and sustained normal alpha-fetoprotein and liver function during a 614-day follow-up period.
MeSH terms
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Adenoviruses, Human / genetics
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
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Biomarkers, Tumor / blood
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Carcinoma, Hepatocellular / blood
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Carcinoma, Hepatocellular / diagnostic imaging
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Carcinoma, Hepatocellular / drug therapy
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Carcinoma, Hepatocellular / therapy*
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Catheters, Indwelling
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Chemoembolization, Therapeutic* / instrumentation
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Combined Modality Therapy
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Doxorubicin / administration & dosage
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Fluorouracil / administration & dosage
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Genes, p53*
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Genetic Therapy*
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Genetic Vectors / administration & dosage
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Genetic Vectors / therapeutic use
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Hepatitis B, Chronic / complications
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Humans
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Liver Neoplasms / blood
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Liver Neoplasms / diagnostic imaging
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Liver Neoplasms / drug therapy
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Liver Neoplasms / therapy*
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Male
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Middle Aged
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Neoplasm Proteins / blood
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Organoplatinum Compounds / administration & dosage
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Organoplatinum Compounds / therapeutic use*
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Oxaliplatin
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Remission Induction
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Tomography, X-Ray Computed
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alpha-Fetoproteins / analysis
Substances
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Biomarkers, Tumor
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Neoplasm Proteins
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Organoplatinum Compounds
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alpha-Fetoproteins
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Oxaliplatin
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Doxorubicin
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Fluorouracil