A patient with huge hepatocellular carcinoma who had a complete clinical response to p53 gene combined with chemotherapy and transcatheter arterial chemoembolization

Anticancer Drugs. 2009 Jun;20(5):403-7. doi: 10.1097/CAD.0b013e328323d6b8.

Abstract

The prognosis of hepatocellular carcinoma (HCC) is poor and current therapies are largely ineffective. Transcatheter arterial chemoembolization is a standard treatment option for patients with unresectable HCC, especially when combined with other therapies. We report a 62-year-old male with huge HCC. The patient was first treated with adenovirus-mediated wild-type p53 gene (Ad-p53, gendicine) combined with oxaliplatin (200 mg) and transcatheter arterial chemoembolization or transcatheter arterial chemotherapy for two cycles. Review showed tumor shrinkage and a decrease in alpha-fetoprotein. Oxaliplatin was stopped because of side effects. Then the patient was treated with a tumor feeding arterial injection of Ad-p53 (1 x 10 viral particles) twice and Ad-p53 (1 x 10 viral particles) followed by 5-fluorouracil (500-750 mg) six times through port-catheter system. We observed marked tumor shrinkage and sustained normal alpha-fetoprotein and liver function during a 614-day follow-up period.

Publication types

  • Case Reports

MeSH terms

  • Adenoviruses, Human / genetics
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Biomarkers, Tumor / blood
  • Carcinoma, Hepatocellular / blood
  • Carcinoma, Hepatocellular / diagnostic imaging
  • Carcinoma, Hepatocellular / drug therapy
  • Carcinoma, Hepatocellular / therapy*
  • Catheters, Indwelling
  • Chemoembolization, Therapeutic* / instrumentation
  • Combined Modality Therapy
  • Doxorubicin / administration & dosage
  • Fluorouracil / administration & dosage
  • Genes, p53*
  • Genetic Therapy*
  • Genetic Vectors / administration & dosage
  • Genetic Vectors / therapeutic use
  • Hepatitis B, Chronic / complications
  • Humans
  • Liver Neoplasms / blood
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / therapy*
  • Male
  • Middle Aged
  • Neoplasm Proteins / blood
  • Organoplatinum Compounds / administration & dosage
  • Organoplatinum Compounds / therapeutic use*
  • Oxaliplatin
  • Remission Induction
  • Tomography, X-Ray Computed
  • alpha-Fetoproteins / analysis

Substances

  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Organoplatinum Compounds
  • alpha-Fetoproteins
  • Oxaliplatin
  • Doxorubicin
  • Fluorouracil