Background: Coronary artery disease (CAD) is one of the most common forms of heart diseases. Monocyte chemoattractant protein-1 gene (MCP-1, CCL2) has been considered one of the candidate genes that play a role in atherogenesis of CAD. Recently, the association of a single nucleotide polymorphism (SNP) in the MCP-1 gene promoter (-2518A>G) and CAD has been investigated with controversial results.
Methods: The -2518A>G polymorphism of MCP-1 was determined in 502 CAD patients and 410 control subjects to investigate the possible involvement of MCP-1 in CAD.
Results: No significant differences in the genotype or allele frequencies were revealed between subjects with and without CAD (P=0.581 and 0.310, respectively). Further stratification analysis by gender or age and analysis of clinical features in relation to myocardial infarction also yielded negative results.
Conclusion: -2518A>G polymorphism of MCP-1 does not seem to contribute substantially to CAD in Han Chinese.