Abstract
Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins (IGFBPs) might play a pathogenic role in heart failure. We showed significantly increased myocardial IGFBP-3 expression (investigated by real-time polymerase chain reaction) and apoptosis (detected by flow cytometry) in 23 failing hearts from patients undergoing cardiac transplantation for end-stage dilated or ischemic cardiomyopathy, when compared with 10 controls. Higher IGF-1 mRNA levels were shown only in end-stage dilated cardiomyopathy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Cardiomyopathy, Dilated / genetics*
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Cardiomyopathy, Dilated / surgery*
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DNA Primers
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Female
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Gene Expression Regulation
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Heart Failure / etiology
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Heart Failure / surgery
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Heart Transplantation / physiology*
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Humans
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Insulin-Like Growth Factor Binding Protein 3 / genetics*
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Insulin-Like Growth Factor I / genetics*
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Male
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Middle Aged
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Myocardial Ischemia / genetics
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RNA, Messenger / genetics
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Ventricular Function, Left / physiology
Substances
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DNA Primers
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Insulin-Like Growth Factor Binding Protein 3
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RNA, Messenger
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Insulin-Like Growth Factor I