Myocardial insulin-like growth factor-1 and insulin-like growth factor binding protein-3 gene expression in failing hearts harvested from patients undergoing cardiac transplantation

J Heart Lung Transplant. 2009 Apr;28(4):402-5. doi: 10.1016/j.healun.2008.12.022.

Abstract

Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins (IGFBPs) might play a pathogenic role in heart failure. We showed significantly increased myocardial IGFBP-3 expression (investigated by real-time polymerase chain reaction) and apoptosis (detected by flow cytometry) in 23 failing hearts from patients undergoing cardiac transplantation for end-stage dilated or ischemic cardiomyopathy, when compared with 10 controls. Higher IGF-1 mRNA levels were shown only in end-stage dilated cardiomyopathy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cardiomyopathy, Dilated / genetics*
  • Cardiomyopathy, Dilated / surgery*
  • DNA Primers
  • Female
  • Gene Expression Regulation
  • Heart Failure / etiology
  • Heart Failure / surgery
  • Heart Transplantation / physiology*
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3 / genetics*
  • Insulin-Like Growth Factor I / genetics*
  • Male
  • Middle Aged
  • Myocardial Ischemia / genetics
  • RNA, Messenger / genetics
  • Ventricular Function, Left / physiology

Substances

  • DNA Primers
  • Insulin-Like Growth Factor Binding Protein 3
  • RNA, Messenger
  • Insulin-Like Growth Factor I