Abstract
Recent studies of cytochrome P-450 gene polymorphism showed that it may influence the outcome of treatment of Helicobacter pylori (Hp) infection. The literature data concerning effects of genetic factors on the results of eradication therapy of peptic ulcer in the Russian population are scarce and the problem needs further investigation. The aim of this work was to examine CYP2C19 polymorphism in a mixed population of the city and region of Moscow and evaluate its effect on the efficiency of eradication therapy of Hp infection. The prospective study of a cohort of 82 patients with Hp-induced gastric and duodenal ulcers examined in conformity with the current health care standards. All the patients received first line eradication therapy during 7 days. Its efficiency was found to be dependent on CYP2C19 polymorphism among other factors.
MeSH terms
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Adult
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Aryl Hydrocarbon Hydroxylases / genetics*
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Biopsy
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Cytochrome P-450 CYP2C19
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Cytochrome P-450 Enzyme System / genetics
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DNA, Bacterial / genetics*
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Duodenal Ulcer / drug therapy
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Duodenal Ulcer / genetics*
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Duodenal Ulcer / microbiology
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Endoscopy, Gastrointestinal
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Female
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Follow-Up Studies
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Helicobacter Infections / drug therapy
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Helicobacter Infections / genetics*
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Helicobacter Infections / microbiology
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Helicobacter pylori / drug effects
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Helicobacter pylori / genetics*
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Helicobacter pylori / isolation & purification
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Humans
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Intestinal Mucosa / microbiology
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Intestinal Mucosa / pathology
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Male
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Polymorphism, Genetic*
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Prospective Studies
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Stomach Ulcer / drug therapy
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Stomach Ulcer / genetics*
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Stomach Ulcer / microbiology
Substances
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DNA, Bacterial
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Cytochrome P-450 Enzyme System
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Aryl Hydrocarbon Hydroxylases
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CYP2C19 protein, human
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Cytochrome P-450 CYP2C19