[Genetic markers of predisposition to infectious complications in neonatal infants with respiratory distress syndrome]

R Z Bogdanova; E Ts Tsydenzhapov; A I Fatykhova; V V Viktorov; T V Viktorova; P I Mironov

[Genetic markers of predisposition to infectious complications in neonatal infants with respiratory distress syndrome]

Anesteziol Reanimatol. 2009 Jan-Feb:(1):46-8.

[Article in Russian]

Authors

R Z Bogdanova, E Ts Tsydenzhapov, A I Fatykhova, V V Viktorov, T V Viktorova, P I Mironov

PMID: 19348329

Abstract

Neonatal respiratory distress syndrome (NRDS) is the commonest cause of death and morbidity of the newborn. A genetic risk for NRDS is currently recognized. The aim of this study was to determine whether there was an association of the polymorphisms of the SP-B, SP-D genes and the interleukins (IL)-1alpha, IL-10 genes with the development of infectious complications in neonatal infants with the respiratory distress syndrome. It was found that the certain genotypes by the polymorphic loci of surfactant proteins and interleukins might be associated with infectious diseases in the newborn with respiratory distress syndrome.

Publication types

English Abstract

MeSH terms

Case-Control Studies
Female
Genetic Markers
Genetic Predisposition to Disease*
Humans
Infant, Newborn
Interleukin-10 / genetics
Interleukin-1alpha / genetics
Male
Pneumonia / etiology
Pneumonia / genetics*
Polymorphism, Single Nucleotide
Pulmonary Surfactant-Associated Protein B / genetics
Pulmonary Surfactant-Associated Protein D / genetics
Respiratory Distress Syndrome, Newborn / complications
Respiratory Distress Syndrome, Newborn / genetics*
Sepsis / etiology
Sepsis / genetics*

Substances

Genetic Markers
IL10 protein, human
Interleukin-1alpha
Pulmonary Surfactant-Associated Protein B
Pulmonary Surfactant-Associated Protein D
Interleukin-10