Abstract
In the present study, we investigated the influence of HLA class I and class II genes in the response to interferon-beta (IFNbeta) in multiple sclerosis (MS) patients. HLA-A, -B, -C, -DRB1, -DQA1, and -DQB1 DNA typing was performed by polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) in a cohort of 149 relapsing-remitting MS patients classified into IFNbeta responders (n=74) and non-responders (n=75) based on stringent clinical criteria. Distribution of HLA class I and class II alleles individually and the HLA-DR2 haplotype was similar between responders and non-responders to treatment. These findings do not support a role of the HLA class I and class II genes as modifiers of the response to IFNbeta.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Cohort Studies
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DNA Mutational Analysis
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Drug Resistance / genetics*
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Drug Resistance / immunology
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Female
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Gene Frequency / genetics
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Genetic Testing
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Genotype
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Haplotypes / genetics
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Histocompatibility Antigens Class I / analysis
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Histocompatibility Antigens Class I / blood
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Histocompatibility Antigens Class I / genetics*
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Histocompatibility Antigens Class II / analysis
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Histocompatibility Antigens Class II / blood
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Histocompatibility Antigens Class II / genetics*
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Humans
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Immunologic Factors / administration & dosage
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Interferon-beta / administration & dosage*
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Male
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Multiple Sclerosis, Relapsing-Remitting / blood
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Multiple Sclerosis, Relapsing-Remitting / drug therapy*
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Multiple Sclerosis, Relapsing-Remitting / genetics*
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Predictive Value of Tests
Substances
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Histocompatibility Antigens Class I
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Histocompatibility Antigens Class II
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Immunologic Factors
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Interferon-beta