Abstract
We report on an acute myeloid leukemia in a neonate whose mother was exposed to diethylstilboestrol in utero. The newborn presented with leukemia cutis, hemorrhagic skin lesions, hyperleucocytosis and disseminated intravascular coagulation. A bone marrow examination confirmed the diagnosis of acute monocytic leukemia with a t(11;19) MLL-ELL fusion transcript. Chemotherapy was initiated but the child developed a bilateral pulmonary infection that led to fatal respiratory distress. This case shows acute myeloid leukemia and the third pediatric leukemia reported after maternal diethylstilboestrol exposure.
(c) 2009 Wiley-Liss, Inc.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Diethylstilbestrol / adverse effects*
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Estrogens, Non-Steroidal / adverse effects*
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Female
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Humans
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In Situ Hybridization, Fluorescence
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Infant, Newborn
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Infertility, Female / chemically induced
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Leukemia, Myeloid, Acute / chemically induced*
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Leukemia, Myeloid, Acute / drug therapy
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Leukemia, Myeloid, Acute / genetics
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Male
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Mothers
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Myeloid-Lymphoid Leukemia Protein
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Oncogene Proteins, Fusion
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Pedigree
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Pregnancy
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Prenatal Exposure Delayed Effects / chemically induced*
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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Estrogens, Non-Steroidal
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MLL-ELL fusion protein, human
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Oncogene Proteins, Fusion
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Myeloid-Lymphoid Leukemia Protein
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Diethylstilbestrol