Abstract
CENP-A is a histone H3-like protein specific to centromeres that is essential for kinetochore formation and accurate chromosome segregation in eukaryotes. Recent studies (Dunleavy et al., 2009; Foltz et al., 2009; Perpelescu et al., 2009; Pidoux et al., 2009; Williams et al., 2009) analyze CENP-A binding proteins required for the recruitment of CENP-A to centromeres in humans and in fission yeast, bringing us closer to understanding how centromere identity is faithfully propagated.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Autoantigens / genetics
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Autoantigens / metabolism*
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Centromere / genetics
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Centromere / metabolism
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Centromere Protein A
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Chromosomal Proteins, Non-Histone / genetics
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Chromosomal Proteins, Non-Histone / metabolism*
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Chromosome Segregation*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Histones / metabolism
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Humans
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Protein Binding
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Schizosaccharomyces / metabolism*
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Schizosaccharomyces pombe Proteins / genetics
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Schizosaccharomyces pombe Proteins / metabolism
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Trans-Activators / genetics
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Trans-Activators / metabolism
Substances
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Autoantigens
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CENPA protein, human
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Centromere Protein A
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Chromosomal Proteins, Non-Histone
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DNA-Binding Proteins
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HJURP protein, human
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Histones
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Nuclear Proteins
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RSF1 protein, human
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Schizosaccharomyces pombe Proteins
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Trans-Activators