Frodos found: Behold the CENP-a "Ring" bearers

Cell. 2009 May 1;137(3):409-12. doi: 10.1016/j.cell.2009.04.035.

Abstract

CENP-A is a histone H3-like protein specific to centromeres that is essential for kinetochore formation and accurate chromosome segregation in eukaryotes. Recent studies (Dunleavy et al., 2009; Foltz et al., 2009; Perpelescu et al., 2009; Pidoux et al., 2009; Williams et al., 2009) analyze CENP-A binding proteins required for the recruitment of CENP-A to centromeres in humans and in fission yeast, bringing us closer to understanding how centromere identity is faithfully propagated.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoantigens / genetics
  • Autoantigens / metabolism*
  • Centromere / genetics
  • Centromere / metabolism
  • Centromere Protein A
  • Chromosomal Proteins, Non-Histone / genetics
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Chromosome Segregation*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Histones / metabolism
  • Humans
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Protein Binding
  • Schizosaccharomyces / metabolism*
  • Schizosaccharomyces pombe Proteins / genetics
  • Schizosaccharomyces pombe Proteins / metabolism
  • Trans-Activators / genetics
  • Trans-Activators / metabolism

Substances

  • Autoantigens
  • CENPA protein, human
  • Centromere Protein A
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • HJURP protein, human
  • Histones
  • Nuclear Proteins
  • RSF1 protein, human
  • Schizosaccharomyces pombe Proteins
  • Trans-Activators