GSTM1, GSTT1 and CYP1A1 polymorphisms and risk of oral cancer: a case-control study in Jakarta, Indonesia

Asian Pac J Cancer Prev. 2009 Jan-Mar;10(1):21-6.

Abstract

Purpose: to investigate genetic polymorphisms in GSTM1, GSTT1 and CYP1A1 and the association with the risk of oral cancer in the Jakarta population.

Method: A total of 81 cases and 162 controls matched for age and sex were selected from 5 hospitals in Jakarta. Sociodemographic data using questionnaires were obtained and peripheral blood samples were collected with informed consent for PCR-RFLP assay. Conditional logistic regression analysis was performed to obtain the association between the risk of oral cancer and GSTM1, GSTT1 and CYP1A1 polymorphisms.

Results: GSTM1 and GSTT1 null were slightly overrepresented among cases (60.5% and 45.7% respectively) compared to controls (55.6% and 41.4% respectively), but no statistically significant differences were observed. In contrast, the distribution of CYP1A1 polymorphism was higher among controls compared to cases (52.5 % versus 42.4 %). The odds ratio of null GSTM1 and GSTT1 genotypes was slightly higher compared to wild type genotypes (OR 1.19, 95% CI 0.70-2.02 and OR 1.19, 95% CI 0.72-2.05 respectively). Furthermore, the presence of CYP1A1 polymorphism did not increase the risk of oral cancer (OR 0.70, 95% 0.39-1.25).

Conclusion: Genetic polymorphisms of GSTM1, GSTT1 and CYP1A1 may not be risk factors for oral cancer in the Jakarta population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alcohol Drinking
  • Areca
  • Carcinoma, Squamous Cell / genetics*
  • Case-Control Studies
  • Cytochrome P-450 CYP1A1 / genetics
  • Female
  • Genetic Predisposition to Disease*
  • Glutathione Transferase / genetics*
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms / genetics*
  • Polymorphism, Genetic*
  • Smoking
  • Young Adult

Substances

  • Cytochrome P-450 CYP1A1
  • glutathione S-transferase T1
  • Glutathione Transferase
  • glutathione S-transferase M1