A preliminary association study between brain-derived neurotrophic factor (BDNF) haplotype and late-onset depression in mainland Chinese

J Affect Disord. 2010 Jan;120(1-3):165-9. doi: 10.1016/j.jad.2009.04.032.

Abstract

Objective: The present study aimed to assess the association of genotypes and haplotypes in brain-derived neurotrophic factor (BDNF) polymorphisms with late-onset depression (LOD) in a Chinese Han population.

Method: 144 subjects with LOD and 110 control subjects were recruited for the study, assessed using the Hamilton Rating Scale for Depression, and genotyped for 712G/A, 270C/T, 196A/G and 11757G/C variants by polymerase chain reaction.

Results: No differences were found in the frequencies of the alleles and genotypes of tested BDNF gene between LOD patients and normal group. Interestingly, the distributions of 712G-270T, 196A-11757G, 196G-11757C, 712G-196A-11757G, 712G-196G-11757C, 270C-196A-11757G, 270C-196G-11757C, 712G-270C-196A-11757G, 712G-270C-196G-11757C haplotypes were significantly higher in LOD compared to healthy controls (all P<0.05).

Conclusion: The results tentatively suggest that BDNF haplotypes might be the susceptibility for LOD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Aged
  • Asian People / psychology*
  • Asian People / statistics & numerical data*
  • Brain-Derived Neurotrophic Factor / genetics*
  • China / epidemiology
  • DNA Primers / genetics
  • Depressive Disorder, Major* / diagnosis
  • Depressive Disorder, Major* / ethnology
  • Depressive Disorder, Major* / genetics
  • Diagnostic and Statistical Manual of Mental Disorders
  • Ethnicity / statistics & numerical data*
  • Female
  • Genotype*
  • Haplotypes / genetics*
  • Humans
  • Linkage Disequilibrium / genetics
  • Male
  • Polymerase Chain Reaction
  • Surveys and Questionnaires

Substances

  • Brain-Derived Neurotrophic Factor
  • DNA Primers