Evidence for epistasis between SLC6A4 and a chromosome 4 gene as risk factors in major depression

Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):321-2. doi: 10.1002/ajmg.b.30979.

Abstract

Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the SLC6A4 HTTLPR short allele revealed a linkage peak on chromosome 4 (maximum HLOD = 3.5). This evidence suggests epistasis between SLC6A4 and an unknown gene as risk factors for major depression.

MeSH terms

  • Chromosomes, Human, Pair 4*
  • Depressive Disorder, Major / genetics*
  • Epistasis, Genetic*
  • Genetic Linkage
  • Humans
  • Risk Factors
  • Serotonin Plasma Membrane Transport Proteins / genetics*

Substances

  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins