Abstract
Myotonic dystrophy 1 (MD1) is caused by a CTG expansion in the 3'-unstranslated region of the myotonic dystrophy protein kinase (DMPK) gene. MD1 patients frequently present insulin resistance and increased visceral adiposity. We examined whether DMPK deficiency is a genetic risk factor for high-fat diet-induced adiposity and insulin resistance using the DMPK knockout mouse model. We found that high-fat fed DMPK knockout mice had significantly increased body weights, hypertrophic adipocytes and whole-body insulin resistance compared with wild-type mice. This nutrient-genome interaction should be considered by physicians given the cardiometabolic risks and sedentary lifestyle associated with MD1 patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipocytes / pathology
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Adiposity / genetics
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Adiposity / physiology*
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Animals
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Cell Enlargement
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Dietary Fats / administration & dosage
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Dietary Fats / adverse effects*
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Disease Models, Animal
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Humans
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Insulin Resistance / genetics
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Insulin Resistance / physiology*
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Male
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Mice
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Mice, Knockout
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Myotonic Dystrophy / etiology
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Myotonic Dystrophy / genetics
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Myotonic Dystrophy / pathology
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Myotonic Dystrophy / physiopathology
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Myotonin-Protein Kinase
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Protein Serine-Threonine Kinases / deficiency*
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / physiology
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Risk Factors
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Weight Gain
Substances
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DMPK protein, human
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DMPK protein, mouse
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Dietary Fats
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Myotonin-Protein Kinase
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Protein Serine-Threonine Kinases