Prominent brainstem and cerebellar involvement in multiple sclerosis with psoriasis

G Ganesvaran; J M Greer; M P Pender

doi:10.1177/1352458509103612

Prominent brainstem and cerebellar involvement in multiple sclerosis with psoriasis

Mult Scler. 2009 Jun;15(6):763-6. doi: 10.1177/1352458509103612.

Authors

G Ganesvaran¹, J M Greer, M P Pender

Affiliation

¹ Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

PMID: 19482865
DOI: 10.1177/1352458509103612

Abstract

Introduction: We identified a subgroup of 20 patients with multiple sclerosis (MS) and psoriasis within a total group of 692 patients with MS.

Results: There was a high (80%) incidence of brainstem and/or cerebellar involvement and a high mean (+/-SD) Multiple Sclerosis Severity Score (6.06 +/- 2.88) in this subgroup. Of the patients who were human leukocyte antigen typed, 53% carried the MS-associated allele, DRB1*1501, and 27% carried the psoriasis-associated DRB1*07 allele.

Conclusion: The high incidence of brainstem and cerebellar involvement might be explained by the greater severity of MS and the high frequency (60%) of carriage of DRB1*04, DRB1*07, and/or DRB1*13 alleles, which are associated with brainstem and cerebellar involvement in MS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Brain Stem / pathology*
Cerebellum / pathology*
Female
Genetic Predisposition to Disease / epidemiology
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
Humans
Incidence
Male
Middle Aged
Multiple Sclerosis, Chronic Progressive / epidemiology*
Multiple Sclerosis, Chronic Progressive / genetics
Multiple Sclerosis, Chronic Progressive / pathology
Multiple Sclerosis, Relapsing-Remitting / epidemiology*
Multiple Sclerosis, Relapsing-Remitting / genetics
Multiple Sclerosis, Relapsing-Remitting / pathology
Psoriasis / epidemiology*
Psoriasis / immunology
Severity of Illness Index
Young Adult

Substances

HLA-DR Antigens
HLA-DRB1 Chains
HLA-DRB1*07 antigen
HLA-DRB1*15:01 antigen