Genetic variation in the vitamin D receptor and polycystic ovary syndrome risk

Touraj Mahmoudi

doi:10.1016/j.fertnstert.2009.05.002

Genetic variation in the vitamin D receptor and polycystic ovary syndrome risk

Fertil Steril. 2009 Oct;92(4):1381-1383. doi: 10.1016/j.fertnstert.2009.05.002. Epub 2009 Jun 6.

Author

Touraj Mahmoudi¹

Affiliation

¹ Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute, Tehran, Iran. Electronic address: mahmouditouraj@gmail.com.

PMID: 19501823
DOI: 10.1016/j.fertnstert.2009.05.002

Abstract

The possible association of vitamin D receptor gene FokI, BsmI, ApaI, and TaqI polymorphisms with polycystic ovary syndrome (PCOS) risk, and their influence on insulin resistance and serum levels of insulin in the women with PCOS was examined. The findings of the present study indicate that genetic variation in the vitamin D receptor may affect PCOS development as well as insulin resistance in women with PCOS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation* / physiology
Genotype
Humans
Insulin Resistance / genetics
Linkage Disequilibrium
Middle Aged
Parathyroid Hormone / blood
Polycystic Ovary Syndrome / blood
Polycystic Ovary Syndrome / genetics*
Receptors, Calcitriol / genetics*
Risk Factors
Vitamin D / analogs & derivatives
Vitamin D / blood
Young Adult

Substances

Parathyroid Hormone
Receptors, Calcitriol
Vitamin D
25-hydroxyvitamin D