Genetic markers of predisposition to increased anxiety

M A Kulikova; E V Trushkin; M A Timofeeva; V A Shlepzova; J V Schegolkova; N V Maluchenko; A G Tonevitsky

doi:10.1007/s10517-009-0373-x

Genetic markers of predisposition to increased anxiety

Bull Exp Biol Med. 2008 Dec;146(6):774-8. doi: 10.1007/s10517-009-0373-x.

[Article in English, Russian]

Authors

M A Kulikova¹, E V Trushkin, M A Timofeeva, V A Shlepzova, J V Schegolkova, N V Maluchenko, A G Tonevitsky

Affiliation

¹ All-Russian Research Institute of Sports and Physical Education, Moscow, Russia.

PMID: 19513381
DOI: 10.1007/s10517-009-0373-x

Abstract

Associations of functional polymorphism in genes of dopamine receptor DRD2, dopamine transporter DAT, and dopamine degrading enzyme COMT with variations in anxiety sensitivity threshold were studied. On the basis of genetic and psychological analysis, an attempt was undertaken to evaluate the relationship of DRD2, DAT and COMT genotypes with values obtained using different anxiety scales. It was found that carriers of VA1(+)9(+) genotype exhibit increased anxiety and significantly differed from individuals with other genotypes. The results were illustrated with model of dopamine diffusion in the extracellular space of the striatum in carriers of different genotypes.

MeSH terms

Adolescent
Adult
Anxiety / genetics*
Catechol O-Methyltransferase / genetics
Dopamine / metabolism
Dopamine Plasma Membrane Transport Proteins / genetics
Female
Genetic Markers
Genetic Predisposition to Disease / genetics*
Genotype
Humans
Male
Models, Biological
Models, Theoretical
Receptors, Dopamine D2 / genetics
Young Adult

Substances

Dopamine Plasma Membrane Transport Proteins
Genetic Markers
Receptors, Dopamine D2
Catechol O-Methyltransferase
Dopamine