No association of DPP6 with amyotrophic lateral sclerosis in an Italian population

Neurobiol Aging. 2011 May;32(5):966-7. doi: 10.1016/j.neurobiolaging.2009.05.014. Epub 2009 Jun 13.

Abstract

We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P=0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyotrophic Lateral Sclerosis / genetics*
  • Cohort Studies
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / genetics*
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Italy
  • Nerve Tissue Proteins / genetics*
  • Polymorphism, Single Nucleotide
  • Potassium Channels / genetics*

Substances

  • Nerve Tissue Proteins
  • Potassium Channels
  • DPP6 protein, human
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases