Abstract
We report a case of acute sacroiliitis with severe disability after only 3 weeks of isotretinoin therapy with graduate reduction of pain, limitation and muscle incompetence after discontinuation of the drug and ACTH-depo injection and Ethodolac therapy. Naranjo probability scale indicated a probable relationship between isotretinoin therapy and bilateral sacroiliitis. We discussed possible mechanisms of sacroiliitis and disability due to isotretinoin treatment.
MeSH terms
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Acne Vulgaris / drug therapy
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Adrenocorticotropic Hormone / therapeutic use
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Adult
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Arthralgia / chemically induced*
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Arthralgia / pathology
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Arthralgia / physiopathology
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Arthritis / chemically induced*
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Arthritis / pathology
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Arthritis / physiopathology
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Dermatologic Agents / adverse effects*
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Disability Evaluation
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Edema / chemically induced
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Edema / pathology
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Etodolac / therapeutic use
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Humans
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Iatrogenic Disease / prevention & control
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Isotretinoin / adverse effects*
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Low Back Pain / chemically induced
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Low Back Pain / pathology
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Low Back Pain / physiopathology
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Magnetic Resonance Imaging
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Male
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Muscle Weakness / etiology
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Muscle Weakness / physiopathology
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Radiography
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Sacroiliac Joint / diagnostic imaging
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Sacroiliac Joint / drug effects*
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Sacroiliac Joint / pathology
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Treatment Outcome
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Whole Body Imaging / methods
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Dermatologic Agents
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Etodolac
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Adrenocorticotropic Hormone
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Isotretinoin