DHFR 19-bp insertion/deletion polymorphism and MTHFR C677T in adult acute lymphoblastic leukaemia: is the risk reduction due to intracellular folate unbalancing?

Am J Hematol. 2009 Aug;84(8):526-9. doi: 10.1002/ajh.21451.
No abstract available

Publication types

  • Letter
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Folic Acid / genetics*
  • Folic Acid / metabolism
  • Genetic Predisposition to Disease*
  • Humans
  • INDEL Mutation*
  • Italy
  • Methylenetetrahydrofolate Dehydrogenase (NAD+) / genetics*
  • Methylenetetrahydrofolate Dehydrogenase (NAD+) / metabolism
  • Middle Aged
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / metabolism
  • Polymorphism, Genetic*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Tetrahydrofolate Dehydrogenase / genetics*
  • Tetrahydrofolate Dehydrogenase / metabolism

Substances

  • Neoplasm Proteins
  • Folic Acid
  • Methylenetetrahydrofolate Dehydrogenase (NAD+)
  • Tetrahydrofolate Dehydrogenase