Sulfonylurea receptor 1 subunits of ATP-sensitive potassium channels and myocardial ischemia/reperfusion injury

Trends Cardiovasc Med. 2009 Feb;19(2):61-7. doi: 10.1016/j.tcm.2009.04.008.

Abstract

K(ATP) channels are generally cardioprotective under conditions of metabolic impairment, consisting of pore-forming (Kir6.1 and/or Kir6.2) and sulphonylurea-binding, modulatory subunits [sulfonylurea receptor (SUR) 1, 2A, or 2B]. Cardiovascular K(ATP) channels are generally thought to consist of Kir6.2/SUR2A subunits (in the case of heart muscle) or Kir6.1/SUR2B subunits (smooth muscle), whereas SUR1-containing channels have well-documented roles in pancreatic insulin release. Recent data, however, demonstrated the presence of SUR1 subunits in mouse cardiac tissue (particularly in atria) and a surprising protection from myocardial ischemia/reperfusion in SUR1-null mice. Here, we review some of the extra-pancreatic roles assigned to SUR1 subunits and consider whether these might be involved in the sequelae of ischemia/reperfusion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / drug effects
  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism*
  • Animals
  • Coronary Vessels / metabolism
  • Heart Atria / metabolism
  • Heart Ventricles / metabolism
  • Humans
  • KATP Channels / drug effects
  • KATP Channels / genetics
  • KATP Channels / metabolism*
  • Mice
  • Mice, Knockout
  • Mitochondria, Heart / metabolism
  • Myocardial Reperfusion Injury / etiology
  • Myocardial Reperfusion Injury / metabolism*
  • Myocardial Reperfusion Injury / prevention & control
  • Myocardium / metabolism*
  • Potassium Channels, Inwardly Rectifying / drug effects
  • Potassium Channels, Inwardly Rectifying / genetics
  • Potassium Channels, Inwardly Rectifying / metabolism*
  • Receptors, Drug / drug effects
  • Receptors, Drug / genetics
  • Receptors, Drug / metabolism*
  • Sulfonylurea Compounds / adverse effects
  • Sulfonylurea Receptors

Substances

  • ABCC8 protein, human
  • ABCC9 protein, human
  • ATP-Binding Cassette Transporters
  • Abcc8 protein, mouse
  • Abcc9 protein, mouse
  • KATP Channels
  • Kir6.2 channel
  • Potassium Channels, Inwardly Rectifying
  • Receptors, Drug
  • Sulfonylurea Compounds
  • Sulfonylurea Receptors