Formin-binding proteins: modulators of formin-dependent actin polymerization

Biochim Biophys Acta. 2010 Feb;1803(2):174-82. doi: 10.1016/j.bbamcr.2009.06.002. Epub 2009 Jul 7.

Abstract

Formins represent a major branch of actin nucleators along with the Arp2/3 complex, Spire and Cordon-bleu. Formin-mediated actin nucleation requires the formin homology 2 domain and, although the nucleation per se does not require additional factors, formin-binding proteins have been shown to be essential for the regulation of formin-dependent actin assembly in vivo. This regulation could be accomplished by formin-binding proteins being directly involved in formin-driven actin nucleation, by formin-binding proteins influencing the activated state of the formins, by linking formin-driven actin polymerization to Arp2/3 driven actin polymerization, or by influencing the subcellular localization of the formins. This review article will focus on mammalian formin-binding proteins and their roles during vital cellular processes, such as cell migration, cell division and intracellular trafficking.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin-Related Protein 2-3 Complex / metabolism
  • Actins / metabolism*
  • Animals
  • Carrier Proteins / metabolism*
  • Cell Polarity
  • Fatty Acid-Binding Proteins
  • Fetal Proteins / genetics
  • Fetal Proteins / metabolism*
  • Formins
  • Humans
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism*
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Profilins / metabolism
  • Signal Transduction / physiology
  • src-Family Kinases / metabolism

Substances

  • Actin-Related Protein 2-3 Complex
  • Actins
  • Carrier Proteins
  • Fatty Acid-Binding Proteins
  • Fetal Proteins
  • Fnbp1 protein, mouse
  • Formins
  • Microfilament Proteins
  • Nuclear Proteins
  • Profilins
  • src-Family Kinases