Abstract
Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2Rgamma(null) mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid beta2microglobulin(null) mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc1.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / therapeutic use*
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Artemisinins / therapeutic use
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Artesunate
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Chloroquine / therapeutic use
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Disease Models, Animal*
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Erythrocytes / parasitology
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Humans
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Interleukin Receptor Common gamma Subunit / genetics
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Interleukin Receptor Common gamma Subunit / physiology*
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Kinetics
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Malaria, Falciparum / drug therapy*
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Malaria, Falciparum / physiopathology
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Mice
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Mice, Inbred NOD
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Mice, SCID
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Pyridones / therapeutic use
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Pyrimethamine / therapeutic use
Substances
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Antimalarials
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Artemisinins
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Interleukin Receptor Common gamma Subunit
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Pyridones
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4-pyridone
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Artesunate
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Chloroquine
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Pyrimethamine