Abstract
A patient with chronic lymphocytic leukemia (CLL) transforming into a small non-cleaved cell lymphoma (SNCL) with the occurrence of a t(8;22) is described. The SNCL and the CLL were both found to have a germline lambda light chain gene configuration and the same heavy chain and kappa light chain gene rearrangements. The SNCL was CD10 (CALLA) negative and appeared to be CD5 negative. It is concluded that the SNCL is derived from the CLL and that activation of the c-myc oncogene may have played a role in this transformation.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Bone Marrow / immunology
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Bone Marrow / pathology
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Cell Transformation, Neoplastic / genetics*
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DNA, Neoplasm / analysis
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Humans
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Immunoglobulin lambda-Chains / genetics
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Karyotyping
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
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Leukemia, Lymphocytic, Chronic, B-Cell / immunology
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology
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Lymphocytes / immunology
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Lymphocytes / pathology*
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Lymphoma, Non-Hodgkin / genetics*
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Lymphoma, Non-Hodgkin / immunology
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Lymphoma, Non-Hodgkin / pathology
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Male
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Middle Aged
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Mitotic Index
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Phenotype
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Translocation, Genetic
Substances
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DNA, Neoplasm
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Immunoglobulin lambda-Chains